Modulating pathological oscillations by rhythmic non-invasive brain stimulation—a therapeutic concept?

A large amount of studies of the last decades revealed an association between human behavior and oscillatory activity in the human brain. Alike, abnormalities of oscillatory activity were related with pathological behavior in many neuropsychiatric disorders, such as in Parkinson's disease (PD) or in schizophrenia (SCZ). As a therapeutic tool, non-invasive brain stimulation (NIBS) has demonstrated the potential to improve behavioral performance in patients suffering from neuropsychiatric disorders. Since evidence accumulates that NIBS might be able to modulate oscillatory activity and related behavior in a scientific setting, this review focuses on discussing potential interventional strategies to target abnormalities in oscillatory activity in neuropsychiatric disorders. In particular, we will review oscillatory changes described in patients after stroke, with PD or suffering from SCZ. Potential ways of targeting interventionally the underlying pathological oscillations to improve related pathological behavior will be further discussed.